Led by associate professor of pathology and Yale Cancer Center member Don Nguyen, PhD, the researchers analyzed RNA from patients with disease that was limited to the lungs as well as cancers that had spread. They also studied animal models of LUAD to identify common pathways.
The researchers found that aggressive LUAD cells expressed a number of proteins that allow them to persist outside the lungs in small numbers. They observed that the tumor cells that spread to the brain were able to utilize an extracellular molecule, which shields them from their hostile surroundings. “These occult lung cancer cells have found a unique way to co-opt the ‘brain microenvironment’ and survive,” said Nguyen. The study findings have already led to a collaboration with a pharmaceutical company to test drugs targeting that pathway, he said.