Negative regulator of natural killer cell maturation discovered

It also shows that Foxo1 exerts its inhibitory effects by blocking transcription of the gene that encodes Tbx21, which is a known positive regulator of NK-cell development and function. The research was reported in the journal Immunity. “We discovered a pathway that cancer cells may use to block NK-cell function and evade immune responses,” says … Continue reading “Negative regulator of natural killer cell maturation discovered”

It also shows that Foxo1 exerts its inhibitory effects by blocking transcription of the gene that encodes Tbx21, which is a known positive regulator of NK-cell development and function.

The research was reported in the journal Immunity.

“We discovered a pathway that cancer cells may use to block NK-cell function and evade immune responses,” says principal investigator Jianhua Yu, PhD, assistant professor of medicine and a member of the OSUCCC — James Leukemia Research Program.

“The findings may provide us an opportunity to enhance NK-cell antitumor activity,” he adds.

Yu and his colleagues used an animal model and human NK cells for the study. Key technical findings include:

  • Foxo1 and Foxo3 control NK-cell maturation, but Foxo1 plays the major role;
  • Reducing Foxo1 expression enhances NK-cell maturation;
  • Foxo1 suppression of Tbx21 expression involves different mechanisms in human and mouse NK cells.

Author: Joe Lovrek

Born in Houston, Raised in Trinity Texas

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