Taste bud maintenance in mice requires Hedgehog signaling

To keep one’s sense of taste, the taste buds and specialized mounds of tissue they reside in, called taste papillae, must be constantly renewed, with taste bud cells lasting an average of just 10 days. Scientists investigated the role of the Hedgehog signaling pathway, an important regulator of development and cell differentiation, in maintaining the … Continue reading “Taste bud maintenance in mice requires Hedgehog signaling”

To keep one’s sense of taste, the taste buds and specialized mounds of tissue they reside in, called taste papillae, must be constantly renewed, with taste bud cells lasting an average of just 10 days. Scientists investigated the role of the Hedgehog signaling pathway, an important regulator of development and cell differentiation, in maintaining the dynamic taste buds and papillae. They used a panel of mouse models that enabled them to block, in some cases reversibly, regulatory GLI proteins that are responsible for Hedgehog-driven changes in gene expression. When the Hedgehog pathway was inhibited, taste buds rapidly disappeared and papillae lost their characteristic shape, even though the taste nerves were still present. Once Hedgehog signaling resumed, a significant fraction of the taste buds regenerated.

The study may help explain a common side effect in cancer patients treated with drugs that block the Hedgehog pathway. These individuals often report a loss of taste which gradually returns after treatment is stopped. Preventing the disappearance of taste buds during Hedgehog pathway blockade might reduce the taste loss experienced by these patients. These results raise the possibility that other conditions associated with a taste disturbance may also be explained by changes in the Hedgehog pathway.

Andrzej Dlugosz and Charlotte Mistretta say “We’re pretty excited about these results because they provide the first genetic evidence that Hedgehog signaling is essential for taste bud maintenance in adult animals. Also, with the types of mouse models we used, we can now say that the critical site for Hedgehog signaling in taste organ maintenance is within epithelial cells of the taste papillae, where taste buds reside. If our results in mice reflect what happens in cancer patients who lose their taste when taking Hedgehog pathway inhibitors, it might be possible to get around this side effect if we can find a way to protect taste buds from the effects of the drug. Further, because the sense of taste is so central in our everyday lives for food choices and pleasurable aspects of eating, understanding how taste organ homeostasis is regulated significantly advances our understanding of sensory biology.”

Author: Joe Lovrek

Born in Houston, Raised in Trinity Texas

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