In the Journal of Pathology, Barbara Fingleton, Ph.D., and colleagues establish a role for MMP2 in the development of lung metastases from primary breast cancer. Using mice without the Mmp2 gene, the team found that metastatic tumors in the lung proliferate less in the absence of fibroblast MMP2.
Among the research institutions NCI funds across the United States, it currently designates 68 as Cancer Centers. Largely based in research universities, these facilities are home to many of the NCI-supported scientists who conduct a wide range of intense, laboratory research into cancer’s origins and development. The Cancer Centers Program also focuses on trans-disciplinary research, including population science and clinical research. The centers’ research results are often at the forefront of studies in the cancer field.